Thomas Braun

CryoConvNeXt enables robust identification of low-abundance molecular species in experimental cryo-EM data

CryoConvNeXt improves identification of low-abundance molecular species in cryo-EM data by using deep learning with self-training, outperforming conventional methods in minority-species recall.

Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles

This study shows that alpha-synuclein fibrils cause mitochondrial-derived vesicle budding and structural changes in mitochondria, linking alpha-synuclein aggregation to mitochondrial toxicity.

Affinity-tag-based microfluidic protein isolation enables high-resolution Cryo-EM from minimal starting material

This paper introduces a microfluidic method for isolating tagged proteins from small samples, enabling high-resolution Cryo-EM with reduced volume and time requirements.

Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies

This study identifies structural and functional differences in alpha-synuclein fibrils from Parkinson's disease, Dementia with Lewy Bodies, and Multiple System Atrophy, linking these differences to disease-specific cellular responses and potential therapeutic targets.