Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress
Min-Keun Lee, Seon Min Kim, Sanghyuk Lee, Jin Ho Yang, Chang-Ryul Choi, Ting Miao, Jong-Seo Kim, Norbert Perrimon, Yun Pyo Kang, Hyun‐Woo Rhee
The paper identifies endogenous nucleophilic metabolites that neutralize reactive acyl species, reducing protein acylation and extending lifespan in model organisms.
bioRxiv · Apr 27, 2026 · PreprintBiochemistry