Ting Miao

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress

The paper identifies endogenous nucleophilic metabolites that neutralize reactive acyl species, reducing protein acylation and extending lifespan in model organisms.

Renal Coenzyme A (CoA) Production from VB5 Fuels Stem Cell Proliferation and Tumor Growth

This study shows that renal CoA production from VB5 supports gut stem cell proliferation and tumor growth in Drosophila, with implications for human cancer.

Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila

This paper develops PD-iPCR to detect low-abundance secreted proteins in Drosophila by using nanobodies and tagged proteins, enabling sensitive quantification of hormones like ImpL2.

Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer

The paper identifies a cytokine-lipid axis that links systemic inflammation to hepatic autophagy dysfunction in cancer across species.

Acetyl-CoA mediated autoacetylation of fatty acid synthase in de novo lipogenesis

The paper identifies acetyl-CoA-mediated autoacetylation of FASN at K813 as a regulatory mechanism for de novo lipogenesis in Drosophila larvae.

Peroxisome import stress impairs ribosome biogenesis and induces integrative stress response through eIF2α phosphorylation

This study shows that peroxisome import stress reduces ribosome biogenesis and activates the integrative stress response through eIF2α phosphorylation in both Drosophila and human cells.