Targeted preoptic neuronal activation induces a hypothermic state with metabolic reprogramming and acute cerebroprotection
Aizad Kamal, Juan Liu, Ernesto R. Gonzales, Khairunisa Mohamad Ibrahim, Fan Zhang, Tamara Abou-Antoun, Hannah E Skelton, Javier Kelly Cuenca, Carla M. Yuede, Gary J. Patti, Leah P. Shriver, Jin-Moo Lee, Aaron J. Norris, Eric C. Landsness
The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.
bioRxiv · Oct 24, 2025 · PreprintNeuroscience