Troy J. Comi

This paper introduces Deep-Phase, a deep learning framework that classifies and quantifies drug-induced changes in condensate morphology from microscopy images, revealing insights into nucleolar structure and function.

This study identifies late-stage processing bottlenecks in ribosome biogenesis caused by oncogene activation, which impair ribosome production and limit tumor growth.

The paper shows that molecularly aged ribosomes alter translational dynamics by impairing elongation and increasing ribosome collisions during organismal aging.

The paper maps rRNA processing dynamics in the nucleolus and shows how rRNA processing affects nucleolar phase organization and structure.

The paper introduces RNA-SPRITE to map RNA-RNA spatial proximity genome-wide, revealing conserved mRNA organization and colocalization driven by shared motifs and functional relationships.

The paper analyzes somatic mutations across tissues and individuals using exome sequencing data from GTEx donors, identifying 8,470 variants and providing insights into mutation rates and mechanisms.

The paper identifies brain gene regulatory network plasticity as a mechanism underlying individual differences in honey bee behavior.