Author

Jordy F. Botello

Princeton UniversityORCID 0000-0002-0163-0595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrej KošmrljiD· 3 shared Aya A. Abu-AlfaiD· 3 shared Clifford P. BrangwynneiD· 3 shared Lifei JiangiD· 3 shared Qiwei YuiD· 3 shared Troy J. ComiiD· 3 shared Lennard W WiesneriD· 2 shared Sofia A. QuinodoziD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Andrej KošmrljORCID

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3 papers

Recent·Most cited

Ribosome biogenesis bottlenecks reveal vulnerabilities in cancer

Lifei Jiang, Qiwei Yu, Sofia A. Quinodoz, Jordy F. Botello, Sabreen Alam, Jing Xia, Jonida Trako, Troy J. Comi, Aya A. Abu-Alfa, Yong Wei, Andrej Košmrlj, Yibin Kang, Clifford P. Brangwynne

This study identifies late-stage processing bottlenecks in ribosome biogenesis caused by oncogene activation, which impair ribosome production and limit tumor growth.

bioRxiv · Apr 21, 2026 · PreprintCell Biology

Ribosome Molecular Aging Shapes Translation Dynamics

Jordy F. Botello, Lifei Jiang, Peter J. Metzger, Troy J. Comi, Aya A. Abu-Alfa, Qiwei Yu, Margaret S. Ebert, Minkyu Lee, Lennard W Wiesner, Maya S. Butani, Claire J. Weaver, Andrej Košmrlj, Ileana M. Cristea, Clifford P. Brangwynne

The paper shows that molecularly aged ribosomes alter translational dynamics by impairing elongation and increasing ribosome collisions during organismal aging.

bioRxiv · Mar 9, 2026 · PreprintCell Biology

Mapping and engineering RNA-controlled architecture of the multiphase nucleolus

Sofia A. Quinodoz, Lifei Jiang, Aya A. Abu-Alfa, Troy J. Comi, Hongbo Zhao, Qiwei Yu, Lennard W Wiesner, Jordy F. Botello, Anita Donlic, Elizabeth Soehalim, Prashant Bhat, Christiane Zorbas, Ludivine Wacheul, Andrej Košmrlj, Denis L. J. Lafontaine, , Clifford P. Brangwynne

The paper maps rRNA processing dynamics in the nucleolus and shows how rRNA processing affects nucleolar phase organization and structure.

Nature · Jul 2, 2025Peer-reviewedCell Biology