Identification and characterization of the de novo methyltransferases for eukaryotic N6-methyladenine (6mA)
Ting Cheng, Jiachen Zhang, Haicheng Li, Jinghan Diao, Wenxin Zhang, Junhua Niu, Kensuke Kataoka, Shan Gao
The paper identifies TET1 and TET2 as de novo methyltransferases responsible for 6mA methylation in Tetrahymena thermophila during sexual reproduction, showing their essential role in genome-wide methylation and gene expression.
bioRxiv · Mar 25, 2024 · PreprintMolecular Biology