Junhua Niu

This study identifies DMT3 as a 6mA demethylase in unicellular eukaryotes and shows its role in maintaining transcriptional and developmental integrity by preventing ectopic 6mA deposition at TSS.

This study determines the structural basis of DNA N6-adenine methylation by modeling the AMT1 complex and validating its function through mutagenesis.

SMAC detects DNA N6-methyladenine at the single-molecule level using SMRT CCS data, improving accuracy over existing methods.

The paper identifies two distinct methyltransferase complexes that coordinate to maintain DNA N6-methyladenine (6mA) through different mechanisms during replication and transcription.

The paper identifies TET1 and TET2 as de novo methyltransferases responsible for 6mA methylation in Tetrahymena thermophila during sexual reproduction, showing their essential role in genome-wide methylation and gene expression.

This study identifies a self-regulatory mechanism of the 6mA methyltransferase AMT1 in Tetrahymena thermophila, showing that AMT1 modulates its own transcription through 6mA methylation and affects cell fitness.