Yuanyuan Wang

This study determines the structural basis of DNA N6-adenine methylation by modeling the AMT1 complex and validating its function through mutagenesis.

The paper identifies two distinct methyltransferase complexes that coordinate to maintain DNA N6-methyladenine (6mA) through different mechanisms during replication and transcription.

The paper demonstrates that DNA N6-adenine methylation (6mA) is transmitted semi-conservatively in Tetrahymena thermophila, with AMT1-dependent maintenance and AMT1-independent de novo methylation mechanisms.

This study identifies a self-regulatory mechanism of the 6mA methyltransferase AMT1 in Tetrahymena thermophila, showing that AMT1 modulates its own transcription through 6mA methylation and affects cell fitness.