A distinct class of eukaryotic demethylases safeguards the positional fidelity of N6-methyladenine (6mA)
Junhua Niu, Haoze Yu, Yongqiang Liu, Liqin Nie, Bei Nan, Wenxin Zhang, Ni Song, Shaoqin Rong, Dan Zhou, Shan Gao
This study identifies DMT3 as a 6mA demethylase in unicellular eukaryotes and shows its role in maintaining transcriptional and developmental integrity by preventing ectopic 6mA deposition at TSS.
Proceedings of the National Academy of Sciences · Mar 2, 2026Peer-reviewedGenetics