AMPK- and cGAS-Mediated Dual Sensing of Glucose and dsDNA Synergizes to Enhance Antitumor Immunity
Ruyuan Zhou, Jingyan Pei, Shasha Chen, Qin Shen, Qirou Wu, Shengduo Liu, Chen Chen, Xin‐Hua Feng, Jian Zou, Tingbo Liang, Yan Zhang, Sheng‐Cai Lin, Penghong Song, Chen‐Song Zhang, Qian Zhang, Pinglong Xu
This study identifies a mechanism where AMPK and cGAS-STING signaling synergize through glucose and dsDNA sensing to enhance antitumor immunity in melanoma and colorectal cancer.
bioRxiv · Feb 15, 2025 · PreprintCancer Biology