ALK R1275Q mutation drives expansion of SCP-like cells during sympathoadrenal commitment and primes neuroblastoma initiation.
Mingzhi Liu, Panagiotis Alkinoos Polychronopoulos, Ana Marín Navarro, Verónica Zubillaga, Huaitao Cheng, Qirong Lin, Tzu‐Po Chuang, Jinhye Ryu, Lola Boutin, Yiming Xia, Ann-Sophie Oppelt, Leilei Zhou, Hugo Metzger, Martin Enge, Daniel Bexell, , Margareta Wilhelm
This study shows ALK R1275Q mutation sustains an immature SCP-like cell state during sympathoadrenal commitment, increasing susceptibility to MYCN-driven neuroblastoma initiation.
bioRxiv · Jan 27, 2026 · PreprintCancer Biology