Author

Leilei Zhou

Karolinska InstitutetORCID 0000-0002-2871-3550Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Lola BoutiniD· 3 shared Margareta WilhelmiD· 3 shared Ann-Sophie OppeltiD· 2 shared Anna FalkiD· 2 shared Jinhye Ryu· 2 shared John Inge JohnseniD· 2 shared Ana Marín Navarro· 1 shared Beth CoyleiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Lola BoutinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ALK R1275Q mutation drives expansion of SCP-like cells during sympathoadrenal commitment and primes neuroblastoma initiation.

Mingzhi Liu, Panagiotis Alkinoos Polychronopoulos, Ana Marín Navarro, Verónica Zubillaga, Huaitao Cheng, Qirong Lin, Tzu‐Po Chuang, Jinhye Ryu, Lola Boutin, Yiming Xia, Ann-Sophie Oppelt, Leilei Zhou, Hugo Metzger, Martin Enge, Daniel Bexell, , Margareta Wilhelm

This study shows ALK R1275Q mutation sustains an immature SCP-like cell state during sympathoadrenal commitment, increasing susceptibility to MYCN-driven neuroblastoma initiation.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.

Niek F. H. N. van Bree, Ann-Sophie Oppelt, Susanne Lindström, Leilei Zhou, Lola Boutin, Beth Coyle, Fredrik J. Swartling, John Inge Johnsen, Lars Bräutigam, Margareta Wilhelm

This paper develops a zebrafish model for medulloblastoma drug testing, showing that neural stem cell culture conditions enhance tumor cell homing and aggressiveness, enabling high-throughput screening.

Neuro-Oncology · Oct 8, 2024Peer-reviewedCancer Biology

High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in SHH-medulloblastoma

Leilei Zhou, Niek van Bree, Lola Boutin, Jinhye Ryu, Simon Moussaud, Mingzhi Liu, Magdalena Otrocka, Magnus Olsson, Anna Falk, Margareta Wilhelm

bioRxiv · Jan 31, 2024Cancer Biology