Ann-Sophie Oppelt

The paper shows JAML expression on NK cells is regulated by tumor microenvironment and MHC class I interaction, with implications for NK cell-mediated tumor killing.

This study shows ALK R1275Q mutation sustains an immature SCP-like cell state during sympathoadrenal commitment, increasing susceptibility to MYCN-driven neuroblastoma initiation.

This paper develops a mouse model with a TP53 nonsense mutation to study tumor development and finds it leads to frequent multicentric or metastatic tumors.

This paper develops a zebrafish model for medulloblastoma drug testing, showing that neural stem cell culture conditions enhance tumor cell homing and aggressiveness, enabling high-throughput screening.