Drug-Mediated Control of Receptor Valency Enhances Immune Cell Potency
Paul B. Finn, Michael Chavez, Xinyi Chen, Haifeng Wang, Draven A. Rane, Jitendra Gurjar, Lei S. Qi
This paper develops valency-controlled receptors (VCRs) to enhance CAR functionality by modulating T cell signaling through multivalent ligands, showing improved immune response against tumors.
bioRxiv · Jan 4, 2023 · PreprintSynthetic Biology