Michael Chavez

Programmable Surface Receptor-Mediated Cell Targeting with Designer Antibody-Routed Nanoparticles (DARTs)

The paper introduces DARTs, a platform for programmable cell targeting using antibody-conjugated nanoparticles, identifying new surface antigens for gene editing in neural cells.

Drug-Mediated Control of Receptor Valency Enhances Immune Cell Potency

This paper develops valency-controlled receptors (VCRs) to enhance CAR functionality by modulating T cell signaling through multivalent ligands, showing improved immune response against tumors.

Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation

This study uses single-cell transcriptomics to identify gene regulatory networks and lineage trajectories in human fetal thymic epithelial cells, revealing interferon response pathways that distinguish thymic epithelium from other anterior foregut-derived organs.