Xinyi Chen

A conserved Foxp1-Pde4d axis regulates inflammatory responsiveness

This study identifies a conserved Foxp1-Pde4d regulatory axis that preserves inflammatory responsiveness by controlling cAMP signaling across vertebrate species.

Programmable macromolecule delivery via engineered trogocytosis

This study demonstrates a programmable macromolecule delivery system using engineered trogocytosis to transfer proteins between cells, enabling genome editing and targeted cell ablation.

Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome

This study maps 5-hydroxymethyluracil and chromatin accessibility in Breviolum minutum to explore their genomic distribution and functional roles.

Drug-Mediated Control of Receptor Valency Enhances Immune Cell Potency

This paper develops valency-controlled receptors (VCRs) to enhance CAR functionality by modulating T cell signaling through multivalent ligands, showing improved immune response against tumors.

The chromatin organization of a chlorarachniophyte nucleomorph genome

This study maps open chromatin, transcription, and 3D organization of the nucleomorph genome in Bigelowiella natans, revealing its highly accessible and transcribed state with strong nucleosome positioning and telomeric chromosome interactions.