Cell BiologybioRxivPreprint
mRNA/LNP-mediated expression of a ligand-independent Tie2 pathway activator, COMP-Tie2*, enables sustained endothelial stabilization
Katrin Radloff, Charlotte Maeve Dunne, Oliver Keil…·Daniel Tondera
This paper develops a method to sustain Tie2 activation using engineered mRNA, showing improved endothelial stabilization compared to traditional ligands.