NeurosciencebioRxivPreprint
Piezo2 voltage-block regulates mechanical pain sensitivity
Oscar Sánchez-Carranza, Sampurna Chakrabarti, Johannes Kühnemund…·Gary R. Lewin
The paper shows that mutations at R2756 in PIEZO2 channels reduce voltage-block, increasing mechanosensitivity in nociceptors and causing hypersensitivity to mechanical pain.
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