Oscar Sánchez-Carranza

Mechanically-gated currents in mouse sensory neurons lacking PIEZO2

This study examines mechanosensitive currents in sensory neurons lacking PIEZO2, finding no significant reduction in current sensitivity but a moderate decrease in rapidly adapting currents.

Cluster nanoarchitecture and structural diversity of PIEZO1 at rest and during activation in intact cells

This study uses MINFLUX nanoscopy to show PIEZO1 channels create membrane invaginations and exhibit conformational changes linked to function and cytoskeletal architecture in intact cells.

Mechanosensitive PIEZO2 channels shape coronary artery development

This study shows PIEZO2 channels are critical for coronary artery development, as their absence causes vessel malformations and cardiac issues in mice.

Touch sensation requires the mechanically-gated ion channel Elkin1.

This study identifies Elkin1 as a novel mechanically-activated ion channel essential for touch and pain sensation, independent of Piezo2.

Piezo2 voltage-block regulates mechanical pain sensitivity

The paper shows that mutations at R2756 in PIEZO2 channels reduce voltage-block, increasing mechanosensitivity in nociceptors and causing hypersensitivity to mechanical pain.

Voltage-gating of mechanosensitive PIEZO channels

This study shows PIEZO channels are voltage-gated and can switch to purely voltage-gated mode, with disease mutations altering voltage sensitivity.