G. Wink

A network of bZIP transcription factors and inhibitors enforces differentially proliferative and cytotoxic states in T cells

This study identifies bZIP transcription factors and inhibitors that influence T-cell proliferation and cytotoxicity under exhaustion conditions.

Sense-and-response to intracellular signaling via nucleocytoplasmic localization control of a synthetic transcription factor platform

The paper develops a synthetic biology platform using nucleocytoplasmic localization tags to enable cells to respond to intracellular signals by inducing transgene expression.

Protein design to broadly reprogram engineered T cell function

This paper designs proteins to reprogram T cell signaling pathways, improving CAR-T and TCR-T performance in solid tumor models.