Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation
Arshed Nazmi, Éadaoin W. Griffin, Robert H. Field, Seán Doyle, Edel Hennessy, Martin O’Donnell, Aisling M. Rehill, Anthony W. McCarthy, Dáire Healy, Michelle M. Doran, John P. Lowry, Colm M. Cunningham
This study shows that loss of basal forebrain cholinergic signaling leads to microglial activation and exaggerated inflammatory responses to systemic inflammation.
bioRxiv · Jan 18, 2021 · PreprintNeuroscience