S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication origins.
Simone Ummarino, Larysa Poluben, Alexander K. Ebralidze, Ida Autiero, Yhanzou Zhang, Theodore Paniza, Madhura Deshpande, Johnathan Lee, Mahmoud Adel Bassal, Bon Q. Trinh, Steven P. Balk, Robert C. Flaumenhaft, Jeannine Gerhardt, Sergei M. Mirkin, Daniel Geoffrey Tenen, Annalisa Di Ruscio
The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.
bioRxiv · Oct 19, 2021 · PreprintMolecular Biology