Larysa Poluben

FOXJ1 mediates taxane resistance through regulation of microtubule dynamics

This paper identifies FOXJ1 as a mediator of taxane resistance in prostate cancer by regulating microtubule dynamics, with clinical implications for patient stratification.

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

This study shows that in prostate cancer with TMPRSS2:ERG fusion, androgen deprivation increases AKT activation, which may reduce the effectiveness of AR-targeted therapy, suggesting combination therapy could be beneficial.

CCL19⁺ fibroblasts define a proliferative niche in chronic lymphocytic leukemia

The paper identifies CCL19⁺ fibroblasts as a proliferative niche in chronic lymphocytic leukemia by analyzing single-cell RNA sequencing data and characterizing interactions within lymph nodes.

S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication origins.

The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.