Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
Naci Oz, Hetian Su, Vedat Sari, Praveen K. Patnaik, Rohil Hameed, Jong Hee Song, Derek C. Prosser, Vyacheslav M. Labunskyy, Vadim N. Gladyshev, Nan Hao, Alaattin Kaya
This paper shows that manipulating intracellular ATP levels in yeast through synthetic ATP import extends cellular lifespan and reveals distinct metabolic pathways involved in aging.
bioRxiv · Apr 14, 2025 · PreprintMolecular Biology