Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease
Jenna Libera, Junming Hu, Tuyet-anh Nguyen, Zihan Wang, Sophie J. F. van der Spek, Kamryn Schult, Luke Dorrian, Jordan Majka, Katarnut Tobunluepop, Sambhavi Puri, Alexander Knyshov, Juao‐Guilherme S Rosa, Yuran Ma, Nicholas M. Kanaan, Peter T. Nelson, , Benjamin L. Wolozin
The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.
bioRxiv · May 2, 2025 · PreprintNeuroscience