Author

Juao‐Guilherme S Rosa

Boston UniversityORCID 0000-0002-7452-8313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

Carrie A. Sheeler· 2 shared Katherine A. HameliD· 2 shared Marija CvetanovićiD· 2 shared Stephen GilliatiD· 2 shared Alexander KnyshoviD· 1 shared Alyssa SolesiD· 1 shared Benjamin L. WoloziniD· 1 shared Ella Borgenheimer· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Carrie A. Sheeler

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3 papers

Recent·Most cited

Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

Jenna Libera, Junming Hu, Tuyet-anh Nguyen, Zihan Wang, Sophie J. F. van der Spek, Kamryn Schult, Luke Dorrian, Jordan Majka, Katarnut Tobunluepop, Sambhavi Puri, Alexander Knyshov, Juao‐Guilherme S Rosa, Yuran Ma, Nicholas M. Kanaan, Peter T. Nelson, , Benjamin L. Wolozin

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

bioRxiv · May 2, 2025 · PreprintNeuroscience

Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar ataxia type 1 mice

Juao‐Guilherme S Rosa, Katherine A. Hamel, Carrie A. Sheeler, Ella Borgenheimer, Stephen Gilliat, Alyssa Soles, Ferris J. Ghannoum, Kaelin Sbrocco, Hillary P. Handler, Orion Rainwater, Ryan Kang, Marija Cvetanović

This study examines spatiotemporal changes in astrocyte phenotypes in SCA1 mice, finding region-specific alterations in astrocyte function and homeostasis that may contribute to disease progression.

Cells · Oct 21, 2022Peer-reviewedNeuroscience

Increased vulnerability of Purkinje cells in the posterior cerebellum of SCA1 mice is associated with molecular and cellular alterations related to disease pathology

Katherine A. Hamel, Francisco Emmanuel Labrada-Moncada, Carrie A. Sheeler, Juao‐Guilherme S Rosa, Stephen Gilliat, Ying Zhang, Marija Cvetanović

The paper identifies regional transcriptional and physiological differences in Purkinje cells of the cerebellum in SCA1 mice, showing reduced heterogeneity and increased vulnerability in the posterior cerebellum.

bioRxiv · Feb 24, 2022 · PreprintNeuroscience