Author

Jose P. Jacob

Mission Bio (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam SciambiiD· 1 shared Dennis J. EastburniD· 1 shared Feng GuoiD· 1 shared Hagop M. KantarjianiD· 1 shared Ian BarriD· 1 shared Jairo A. MatthewsiD· 1 shared Jen Quick-ClevelandiD· 1 shared Jennifer A. Geis· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Adam SciambiORCID

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Author profile →

2 papers

Recent·Most cited

Fe(III) heme sets an activation threshold for processing distinct groups of pri-miRNAs in mammalian cells

Sara H. Weitz, Jen Quick-Cleveland, Jose P. Jacob, Ian Barr, Rachel Senturia, Kikuye Koyano, Xinshu Grace Xiao, Shimon Weiss, Feng Guo

The paper investigates how Fe(III) heme availability affects pri-miRNA processing by DGCR8 and identifies a heme affinity threshold for Microprocessor activity.

bioRxiv · Feb 18, 2020 · PreprintMolecular Biology

High-throughput single-cell DNA sequencing of AML tumors with droplet microfluidics

Maurizio Pellegrino, Adam Sciambi, Sebastian Treusch, Robert Durruthy-Durruthy, Kaustubh Gokhale, Jose P. Jacob, Tina X. Chen, Jennifer A. Geis, William M. Oldham, Jairo A. Matthews, Hagop M. Kantarjian, P. Andrew Futreal, Keyur Pravinchandra Patel, Keith W. Jones, Koichi Takahashi, Dennis J. Eastburn

This study develops a microfluidic method for single-cell DNA sequencing of AML tumors, revealing clonal evolution not detectable by bulk sequencing.

Genome Research · Sep 1, 2018Peer-reviewedGenomics