Feng Guo

This study develops 3D-bridge antisense oligonucleotides that enhance exon 44 skipping in dystrophin mRNA, showing improved binding affinity and efficacy compared to conventional ASOs.

The paper introduces SHARCLIP to map RNA-RNA, RNA-protein, and protein-protein contacts in cells, revealing structural mechanisms of splicing and therapeutic targets.

This paper designs structure-based antisense oligonucleotides (ASOs) that inhibit SARS-CoV-2 replication by targeting RNA structures rather than just sequences.

The paper determines the structures of human miR-precursor apical junctions and loops, revealing non-canonical base pairs that contribute to processing efficiency and stability.

The paper investigates how Fe(III) heme availability affects pri-miRNA processing by DGCR8 and identifies a heme affinity threshold for Microprocessor activity.