Hagop M. Kantarjian

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

This study shows that resistant clones are rapidly selected in hematopoietic cell compartments with leukemic stem cell potential before relapse in patients treated with ivosidenib combination therapy.

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

High-throughput single-cell DNA sequencing of AML tumors with droplet microfluidics

This study develops a microfluidic method for single-cell DNA sequencing of AML tumors, revealing clonal evolution not detectable by bulk sequencing.