Therapeutic efficacy of hiMSC-derived Extracellular Vesicles from Serum-containing and Xeno-free media for osteoarthritis treatment
Sayedeh Sana Sayedipour, Jelle Nikkels, Tobias Tertel, Helena E. D. Suchiman, Matilde Balbi, Georgina Shaw, Luis Javier Cruz, Louise van der Weerd, Chiara Gentili, Bernd Giebel, Josephine Mary Murphy, Ingrid Meulenbelt, Y.F. Ramos
This study evaluates the therapeutic effects of hiEVs from different media in an OA mouse model, finding that xeno-free hiEVs reduce joint damage and promote cartilage repair.
bioRxiv · Aug 20, 2025 · PreprintDevelopmental Biology