Nitric oxide synthase inhibition and biological sex define different cardiac responses to cardiometabolic stress in older mice.
June Sun, Alejandro Torres, Joshua Hor, Daniel G. Donner, Helen Kiriazis, Shannen Walker, Simon T. Bond, Natalie A. Mellet, Peter J. Meikle, Adam C. Parslow, Michael L.H. Huang, Monica Kanki, Brian G. Drew, Yow Keat Tham, Julie R. McMullen, Morag J. Young
This study shows that biological sex and nitric oxide synthase inhibition lead to different cardiac responses to cardiometabolic stress in older mice, resulting in distinct HFpEF-like or HFrEF-like phenotypes.
bioRxiv · Sep 3, 2026 · PreprintPathology