An Injectable Antisense Oligonucleotide (ASO) Approach to Treat Obesity in Preclinical Models
Simon T. Bond, Michael F. Keating, Yingying Liu, Christine Yang, Shannen Walker, Aaron W Jurrjens, Kevin H Liu, Adam C. Parslow, Artika P. Nath, Sergio Ruiz Carmona, Michael Inouye, Anna C. Calkin, Brian G. Drew
This paper demonstrates that injectable antisense oligonucleotides (ASO) can prevent and treat obesity in mice without significant loss of lean mass.
bioRxiv · Oct 19, 2026 · PreprintPhysiology