Author

Joshua J. Bowen

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Liam T. McCreaiD· 3 shared Roy H. PerlisiD· 3 shared Steven D. SheridaniD· 3 shared Hana YehiD· 2 shared Rebecca BatorskyiD· 2 shared Yoonjae Song· 2 shared Camilla BoschianiD· 1 shared Jessica M. ThanosiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Liam T. McCreaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial Regulators

Joy E. Horng, Liam T. McCrea, Rebecca Batorsky, Joshua J. Bowen, Camilla Boschian, Yoonjae Song, Roy H. Perlis, Steven D. Sheridan

This study uses CRISPR screening to identify schizophrenia-associated genes that regulate microglial phagocytosis and morphology, revealing potential therapeutic targets.

Neuropsychopharmacology · Apr 16, 2026Peer-reviewedNeuroscience

Atypical antipsychotics alter microglial functions via astrocyte-derived extracellular vesicles

Hana Yeh, Yoonjae Song, Joshua J. Bowen, Liam T. McCrea, Steven D. Sheridan, Roy H. Perlis

This study shows that atypical antipsychotics like clozapine and olanzapine alter microglial functions through astrocyte-derived extracellular vesicles by affecting phagocytosis and motility.

Brain Behavior and Immunity · Oct 10, 2025Peer-reviewedNeuroscience

Identifying brain-penetrant small molecule modulators of human microglia using a cellular model of synaptic pruning

Liam T. McCrea, Rebecca Batorsky, Joshua J. Bowen, Hana Yeh, Jessica M. Thanos, Ting Fu, Roy H. Perlis, Steven D. Sheridan

The paper screens CNS-penetrant compounds to identify small molecules that modulate microglial phagocytosis of synaptosomes, finding 28 compounds with significant effects.

Neuropsychopharmacology · May 9, 2025Peer-reviewedNeuroscience