Liam T. McCrea

This study uses CRISPR screening to identify schizophrenia-associated genes that regulate microglial phagocytosis and morphology, revealing potential therapeutic targets.

This study shows that atypical antipsychotics like clozapine and olanzapine alter microglial functions through astrocyte-derived extracellular vesicles by affecting phagocytosis and motility.

The paper screens CNS-penetrant compounds to identify small molecules that modulate microglial phagocytosis of synaptosomes, finding 28 compounds with significant effects.

This study shows that knocking out CYFIP1 in human microglia reduces synaptic vesicle phagocytosis, morphology changes, and motility, suggesting a role in synaptic pruning related to neurodevelopmental disorders.

This study generates patient-derived microglia-like cells from umbilical cord blood to model fetal brain immune responses to maternal SARS-CoV-2 exposure.