Rebecca Batorsky

The paper identifies an inducible microfold-like cell population in the colon associated with severe Clostridioides difficile infection susceptibility and shows its role in epithelial repair and immune response.

This study uses CRISPR screening to identify schizophrenia-associated genes that regulate microglial phagocytosis and morphology, revealing potential therapeutic targets.

This study develops a co-culture system to study C. difficile interaction with human intestinal epithelium and finds CCL20 expression is upregulated in response to the bacterium.

This study compares salivary and plaque microbiomes in children with and without type 1 diabetes, finding saliva provides better classification accuracy for detecting T1D.

The paper screens CNS-penetrant compounds to identify small molecules that modulate microglial phagocytosis of synaptosomes, finding 28 compounds with significant effects.

The paper shows that Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity, suggesting Hofbauer cells as a noninvasive biomarker for fetal microglial programming.

The paper uses single-cell RNA sequencing to compare fetal brain microglia and Hofbauer cells, revealing shared transcriptional programs and sex-specific differences.

The paper develops a method to detect mitochondrial heteroplasmy using NGS data and evaluates sources of mtDNA for clinical diagnostics.