Author

Joy E. Horng

Harvard UniversityORCID 0000-0001-7702-7381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Liam T. McCreaiD· 3 shared Roy H. PerlisiD· 3 shared Steven D. SheridaniD· 3 shared Ting FuiD· 2 shared Andrea G. EdlowiD· 1 shared Camilla BoschianiD· 1 shared Carl M. SellgreniD· 1 shared Daniel Y. KimiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Liam T. McCreaORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeuroscienceNeuropsychopharmacologyPeer-reviewedApr 16, 2026

Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial Regulators

Joy E. Horng, Liam T. McCrea, Rebecca Batorsky…·Steven D. Sheridan

This study uses CRISPR screening to identify schizophrenia-associated genes that regulate microglial phagocytosis and morphology, revealing potential therapeutic targets.

2 citations

humanCRISPR screen

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NeurosciencebioRxivPreprintOct 24, 2022

Loss of function in the autism and schizophrenia-associated gene CYFIP1 in human microglia supports a role in synaptic pruning

Steven D. Sheridan, Joy E. Horng, Hana Yeh…·Roy H. Perlis

This study shows that knocking out CYFIP1 in human microglia reduces synaptic vesicle phagocytosis, morphology changes, and motility, suggesting a role in synaptic pruning related to neurodevelopmental disorders.

DOI 10.1101/2022.10.24.513576

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintApr 5, 2021

Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects

Karl Petri, Daniel Y. Kim, Kanae E. Sasaki…·Vikram Pattanayak

ONE-seq identifies population-specific off-target effects of CRISPR gene editors using global human genome sequence diversity.

42 citations

humanexperimental assay

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NeuroscienceTranslational PsychiatryPeer-reviewedMar 19, 2021

Umbilical cord blood derived microglia-like cells to model COVID-19 exposure

Steven D. Sheridan, Jessica M. Thanos, Rose M. De Guzman…·Andrea G. Edlow

This study generates patient-derived microglia-like cells from umbilical cord blood to model fetal brain immune responses to maternal SARS-CoV-2 exposure.

21 citations

humanexperimental assay

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