Breaking Free: Development of Circular AAV Cargos for Targeted Seamless Integration in the Liver
Brett Estes, Nisha Gandhi, Jessica R. Von Stetina, Dev Paudel, Angela Xinyi Nan, Parth H. Amin, Joshua Rose, Shuai Tao Wu, Kangni Zheng, Yijun Zhang, Jesse C. Cochrane, Jonathan D. Finn, Jenny Xie
This paper develops circular AAV vectors for DSB-free genomic integration in the liver, demonstrating seamless gene insertion in human hepatocytes and in vivo.
Molecular Therapy — Methods & Clinical Development · May 14, 2025Peer-reviewedBioengineering