Author

Parth H. Amin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:non-human primate· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Brett EstesiD· 3 shared Jenny XieiD· 3 shared Jesse C. CochraneiD· 3 shared Jonathan D. FinniD· 3 shared Angela Xinyi Nan· 2 shared Connor McGinnis· 2 shared Dane Z. HazelbakeriD· 2 shared Daniel J. O’ConnelliD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Brett EstesORCID

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Author profile →

3 papers

Recent·Most cited

Breaking Free: Development of Circular AAV Cargos for Targeted Seamless Integration in the Liver

Brett Estes, Nisha Gandhi, Jessica R. Von Stetina, Dev Paudel, Angela Xinyi Nan, Parth H. Amin, Joshua Rose, Shuai Tao Wu, Kangni Zheng, Yijun Zhang, Jesse C. Cochrane, Jonathan D. Finn, Jenny Xie

This paper develops circular AAV vectors for DSB-free genomic integration in the liver, demonstrating seamless gene insertion in human hepatocytes and in vivo.

Molecular Therapy — Methods & Clinical Development · May 14, 2025Peer-reviewedBioengineering

Curative levels of endogenous gene replacement achieved in non-human primate liver using programmable genomic integration

Jenny Xie, Maike Thamsen Dunyak, Patrick Hanna, Angela Xinyi Nan, Brett Estes, Jesse C. Cochrane, Shuai Wu, Jie Wang, Connor McGinnis, Qiang Wang, Rejina Pokharel, Dev Paudel, Jason Zhang, Dan Li, Parth H. Amin, , Jonathan D. Finn

This paper demonstrates programmable genomic integration in non-human primate liver, achieving curative levels of gene expression in over 50% of liver cells.

bioRxiv · Oct 12, 2024 · PreprintBioengineering

Large Serine Integrase Off-target Discovery and Validation for Therapeutic Genome Editing

Dane Z. Hazelbaker, Japan B. Mehta, Connor McGinnis, Didac Santesmasses, Anne M. Bara, Xiaoyu Liang, Thomas C. Biondi, Tim J. Fennell, Nils Homer, Brett Estes, Jenny Xie, Davood Norouzi, Kaivalya Molugu, Ravindra Amunugama, Chong T. Luo, , Daniel J. O’Connell

The paper develops and validates methods to detect off-target recombination by Large Serine Integrases, finding higher sensitivity than whole genome sequencing.

bioRxiv · Aug 23, 2024 · PreprintGenomics