Microbiome histidine competition mediates dietary control of systemic imidazole propionate
Paola Nol Bernardino, Christian Jacoby, Isaac T. Younker, Joshua Stemczynski, Alexander S. Little, Michael W. Mullowney, Tess H. Brunner, Joyce Ghali, Matteo Fardin, Kelsey Rose, Ramanujam Ramaswamy, Ashley M. Sidebottom, Sarah A. Tersey, Eric G. Pamer, Raghavendra G. Mirmira, , Samuel H. Light
This study shows dietary glutamate influences ImP production via microbial competition, affecting glucose tolerance and systemic ImP levels.
bioRxiv · Jun 23, 2026 · PreprintMicrobiology