Michael W. Mullowney

IDBac: an open-access web platform and compendium for the identification of bacteria by MALDI-TOF mass spectrometry.

IDBac provides a centralized database and platform for bacterial identification via MALDI-TOF MS, enabling spectral comparison and analysis of bacterial isolates.

Microbiome histidine competition mediates dietary control of systemic imidazole propionate

This study shows dietary glutamate influences ImP production via microbial competition, affecting glucose tolerance and systemic ImP levels.

Fecal Metabolite Quantitation for Rapid Assessment of the Gut Microbiome

This paper presents a rapid diagnostic test to measure fecal butyrate and deoxycholic acid concentrations as markers of microbiome function, enabling quick identification of patients with microbiome deficiencies.

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

A computational framework for systematic exploration of biosynthetic diversity from large-scale genomic data

The paper introduces two tools, BiG-SCAPE and CORASON, for analyzing biosynthetic gene clusters in large genomic datasets, demonstrating their utility through validation and discovery of new gene cluster families.