Author

Joshua Straka

Pennsylvania State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Claudia M. NicolaeiD· 3 shared George‐Lucian MoldovaniD· 3 shared Alexandra NusawardhanaiD· 2 shared Anastasia HaleiD· 1 shared Jude B Khatib· 1 shared Lindsey M Pale· 1 shared Tanay ThakariD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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3 shared papersGenetics

Claudia M. NicolaeORCID

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Author profile →

3 papers

Recent·Most cited

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

Anastasia Hale, Alexandra Nusawardhana, Joshua Straka, Claudia M. Nicolae, George‐Lucian Moldovan

bioRxiv · Apr 15, 2026 · PreprintGenetics

CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps

Lindsey M Pale, Jude B Khatib, Alexandra Nusawardhana, Joshua Straka, Claudia M Nicolae, George-Lucian Moldovan

The paper identifies the HELQ-RAD52 axis as a regulator of cisplatin-induced ssDNA gap processing through CRISPR screens in human cells.

bioRxiv · Apr 17, 2024Cancer Biology

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly by ensuring PCNA-dependent CAF-1 recycling

Tanay Thakar, Joshua Straka, Claudia M. Nicolae, George‐Lucian Moldovan

This study identifies lagging strand ssDNA gaps as drivers of fork degradation in BRCA-deficient cells by inhibiting PCNA unloading and CAF-1-dependent nucleosome assembly.

bioRxiv · Nov 8, 2021 · PreprintMolecular Biology