MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression
J. Hofstatter Azambuja, Saigopalakrishna S. Yerneni, Lisa M. Maurer, Hannah E. Crentsil, Gabriela Nogueira Debom, Linda R. Klei, Mei Smyers, Chaim T. Sneiderman, Kristina Elsa Schwab, Rajesh Acharya, Aivi T. Nguyen, Josie L. Emery, John W. Little, Jeffrey A. Meridew, Yijen Lin Wu, , Linda M. McAllister‐Lucas
This study shows that inhibiting MALT1 protease in glioblastoma-associated macrophages reduces immunosuppression and tumor growth by reprogramming macrophages to an M1-like phenotype.
Nature Communications · Aug 10, 2026Peer-reviewedCancer Biology