pH-dependent trapping of cationic amphiphilic drugs perturbs insulin granule homeostasis
Oleksandra Topcheva, Andreas S. Mueller, Marcelo Zoccoler, Martin Neukam, Pamela L. Toledo, Katharina Ganß, Anke Sönmez, Carolin Wegbrod, Carla Münster, Klaus-Peter Knoch, Juha M. Torkko, Sofia Traikov, Michał Grzybek, Michele Solimena
This study shows that cationic amphiphilic drugs (CADs) accumulate in insulin secretory granules via pH-dependent trapping, affecting monoamine storage and pH regulation.
bioRxiv · Feb 20, 2026 · PreprintCell Biology