Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs
Emma C. Carroll, Hyunjun Yang, Wyatt C. Powell, Annemarie F. Charvat, Abby Oehler, Julia G. Jones, Kelly M. Montgomery, Anthony Yung, Zoe Millbern, Alexander I. P. Taylor, Martin Wilkinson, Neil A. Ranson, Sheena E. Radford, Nelson R. Vinueza, William F. DeGrado, , Jason E. Gestwicki
The paper develops a high-throughput method to identify fluoroprobes that distinguish between tau fibril polymorphs using paDSF and chemical screening.
Nature Chemistry · Aug 14, 2025Peer-reviewedBiochemistry