Spatial transcriptome-metabolome integration reveals region-specific glial lipid dysregulation linked to Alzheimer's pathology
Linfeng Xu, Hyunjun Yang, Julio Leon, Xiangpeng Li, Abby Oehler, Cyrus Modavi, Adam R. Abate, Carlo Condello
The paper develops a spatial multi-omic method to study lipid dysregulation in Alzheimer's disease across brain regions in mice, identifying region-specific glial metabolic changes.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience