Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML
Ilias Sinanidis, Panagiotis Tsakiroglou, Benjamin G. Dubner, Rebecca Foertsch, Julia Gondek, InYoung Choi, Bogdan C. Paun, Liang Zhao, Gabriel Ghiaur, William Brian Dalton
The paper identifies serine auxotrophy in AML as a vulnerability driven by PSAT1 suppression, showing sensitivity to serine/glycine restriction and potential therapeutic targeting.
bioRxiv · May 13, 2025 · PreprintCancer Biology