Metabolic Maturation Unveils Left Ventricular Identity in WNT ON/OFF Human Pluripotent Stem Cell-Derived Cardiomyocytes
Joaquín Smucler, Julia Halek, Denisse Saulnier, Sheila Lucía Castañeda, Agustina Scarafía, Guadalupe Amín, Alejandra Guberman, Gustavo Emilio Sevlever, Santiago Miriuka, Lucia Natalia Moro, Ariel Waisman
The paper shows that WNT ON/OFF differentiation generates immature LV cardiomyocytes, which can be matured via metabolic maturation to achieve high-purity LV CMs.
bioRxiv · Dec 30, 2025 · PreprintDevelopmental Biology