Early-Stage Corticostriatal Circuit Hyperactivity Impairs Cholinergic Function and Cognitive Flexibility in an Alzheimer's Model
Yufei S. Huang, Xuan Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn A. de Souza, Julia Hunter, Xin Yi Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang
This paper identifies hyperactivity in the mPFC-to-DMS circuit in 5xFAD mice as a cause of cognitive inflexibility, showing that inhibiting this circuit improves cognitive function and reduces Aβ accumulation.
bioRxiv · Jan 14, 2026 · PreprintNeuroscience