Alexandra S. Bova

Dorsomedial striatal dopamine ramps down during interval timing

The paper investigates dopamine dynamics in the mouse dorsomedial striatum during interval timing and finds that dopamine ramps down before reward delivery, predicts timing behavior, and varies between sexes and with amphetamine.

Neuronal ramping and theta power during freely-moving and head-fixed mouse interval timing.

This study shows that prefrontal neuronal ramping and theta activity occur during both freely-moving and head-fixed interval timing tasks in mice, suggesting they are features of temporal behavior rather than specific motor programs.

Timing, movement, and reward contributions to prefrontal and striatal ramping activity

This study investigates how time estimation, movement, and reward anticipation contribute to prefrontal and striatal ramping activity in mice during interval timing tasks.

Ventral tegmental area dopamine controls timing variability

This study shows that VTA dopamine neurons control timing variability in Parkinson's disease by modulating neural activity during interval timing tasks.

Diverse activity in prefrontal projections promotes temporal control of action

The paper investigates prefrontal projections during interval timing, finding distinct temporal coding and transcriptomic profiles in PFC-MD and PFC-DMS circuits.

Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

This study shows D2-MSNs and D1-MSNs have opposing dynamics but complementary roles in interval timing, revealing how striatal pathways contribute to cognitive timing.

Amphetamine increases timing variability by degrading prefrontal ramping activity

This study shows amphetamine increases timing variability by reducing prefrontal cortex ramping activity and neural interactions in mice.

Sex similarities and dopaminergic differences in interval timing

The paper investigates sex differences in interval timing across humans and rodents, finding no sex differences in timing accuracy or precision but distinct dopaminergic effects in males.

Precisely-timed dopamine signals establish distinct kinematic representations of skilled movements

This study investigates how precisely-timed dopamine signals affect motor skill performance in rats during a complex reaching task, finding abrupt transitions in movement kinematics.